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KMID : 0366220090440020117
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Korean Journal of Hematology
2009 Volume.44 No. 2 p.117 ~ p.121
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A Case of Acute Biphenotype Leukemia after Diagnosis of Pulmonary Alveolar Proteinosis
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Jeong Hong-Ryul
Choi Young-Jin
Chung Joo-Seop
Cho Goon-Jae
Kim Mi-Ra
Cheong Jae-Hoon
Park Su-Bum
Lee Naria
Kim Hyo-Jeong
Lee Ha-Rin
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Abstract
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We present the case of a 34-year-old man with acute biphenotype leukemia that co-expressed B-lymphoid and myeloid antigen after the diagnosis of pulmonary alveolar proteinosis (PAP). The diagnosis of PAP was established by Periodic Acid-Schiff reaction staining on the Video Associated Thoracoscope guided lung biopsy and biphenotype leukemia was revealed by immunohistochemical stains of the blasts harvested from the bone marrow biopsy. Supposedly, PAP follows a hematologic malignancy, yet this case shows the reverse sequence. (Korean J Hematol 2009;44:117-121.)
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KEYWORD
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Pulmonary alveolar proteinosis, Acute biphenotype leukemia, B-lymphoid, Myeloid
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